Endocrine Abstracts

A 67–year-old female patient was transferred to our hospital from a nursing home for high capillary glucose levels and foot ulcer considered as diabetic foot infection. Her past medical history could not be obtained because of mental retardation with unknown etiology and absence of relatives.A purulent foot ulcer sized 4×3 cm was found in right heel. She also had deformities in her hands, feet, and her nose. Peripheral neuropathy was also detec...

Introduction: Polycycstic ovary syndrome (PCOS) is an important disorder in women of reproductive age which is characterised with menstrual dysfunction, anovulation and hyperandrogenism. 5–10% of the female population affected by this syndrome. Nesfatin-1 is a new anorexigenic hormone which is expressed from several regions of hypothalamus and peripheral tissues. Nesfatin-1 is related with obesity, insulin resistance and appetite. We aimed to evaluated the nesfatin-1 leve...

Introduction: Mutations on menin gene are associated with multiple endocrine neoplasia type 1.Case report: Thirty-five year-old male patient was admitted to our hospital with history of recurrent syncope episodes for 5 years which were attributed to hypoglycemia. In physical examination, he had obesity and multiple papillamatous skin lesions on his abdominal region. He had no family history of similar symptoms. His laboratory eveluation was consistent wi...

Introduction: We aimed to determine changes in geriatric assessment of cases with acromegaly.Methods: 26 elderly cases with acromegaly (controlled/uncontrolled: 15/11, F/M: 17/9) were included. 20 age, gender and BMI matched cases without acromegaly composed control group (CG) (F/M: 10/10). Presence of concomitant diseases and educational level were not different between the groups. Cognitive functions were evaluated with Mini Mental State Exam (MMSE), a...

Introduction: Infliximab is a tumour necrosis factor (TNF) α inhibitor and used for the treatment of psoriasis. Herein, we report a case of destructive thyroiditis accompanied by transient thyrotoxicosis resulting from the infliximab therapy for the treatment of psoriasis.Case report: A 57-year-old man suffered from psoriasis and was treated with infliximab therapy for 4 years. Thyroid function tests were normal before infliximab therapy. When the p...

Medullar thyroid cancer (MTK) approximately constitutes 5% of thyroid cancer, over the 25% cases it progresses in familial form. In charge of genetic inherited clinical features in RET protooncogene ‘germ-line’ makes up activating mutations. In post RET mutation in association with tyrosine kinase activation oncogenic cell proliferation is increased. In medullary thyroid cancer persistent and recurrence disease management is complicated, because it is unresponsive to...

Objective: Various effects of glucocorticoids occur in brown adipose tissue depending on their duration of action. As a result of exposure to glucocorticoids, thermogenesis and oxygen use in brown fat tissue are reduced in animal studies. In this study, we aimed to compare the levels of UCP1 (uncoupling protein 1), Irisin, BMP 7 (bone morpogenic protein), PRDM16, which are brown addipose tissue markers, between patients with Cushing’s disease and healthy controls<p c...

Background: Fine needle aspiration biopsy (FNAB) and Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) have proven to be the most valuable diagnostic procedure for preoperative discrimination of benign and malignant thyroid nodules. Thyroid surgery may cause regional scarring and some degree of fibrotic process which may result in problems when collecting FNAB samples and evaluating the cellular abnormalities. In this study, we aimed to determine whether the Bethesd...

Case report: Adrenal pseudocysts are rare bening lesions that usually mimick solid tumors on imaging. Although they are asymptomatic and often discovered incidentally, distinguishing them from clinically important adrenocortical masses may be problematic before surgery. We report the case of a 50-years-old female who was referred to endocrinology outpatient clinic with a 54×58×50 mm sized mass in the left adrenal gland. Abdominal MRI which was performed because of ri...

Atypical tumors were identified in 15% of pituitary adenomas, and they tended to be aggressive, invasive macroadenomas. WHO classification of atypical pituitary adenomas include; Ki-67 proliferative index >3%, excessive p53 immunoreactivity, and ≥ 2 mitotic figures per 10 high-powered fields. Pituitary carcinomas are extremely rare tumors with cerebrospinal or extracranial metastasis.Case: A 31 years old man with symptoms of stuffy nose and sno...